Delay of nomifensine-induced seizures by fusaric acid, alpha-methyltyrosine and haloperidol.

Abstract

An In Vivo model is presented to determine the effects of alpha methyl-para-tyrosine methyl ester (MPT), fusaric acid (FA), and haloperidol on nomifensine-induced seizures. All three drugs were active with haloperidol having the greatest effect on delay of onset to convulsion. The results suggest that both dopamine and norepinephrine are involved in nomifensive-induced convulsions and that administering agents known to lower both dopamine and/or norepinepherine in the rat brain delays onset but that haloperidol, which specifically blocks post-synaptic dopamine receptors, had the greatest activity.

• Authors: M R Huff, G G Meadows, W E Johnson
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 51 Issue 3 Pg. 413-6 (Mar 1986) ISSN: 0034-5164 [Print] United States
• PMID: 3704316 (Publication Type: Journal Article)

Chemical References

• Methyltyrosines
• Picolinic Acids
• Nomifensine
• Haloperidol
• Fusaric Acid
• Dopamine
• Norepinephrine

Topics

• Animals
• Brain (physiopathology)
• Dopamine (physiology)
• Fusaric Acid (pharmacology)
• Haloperidol (pharmacology)
• Male
• Methyltyrosines (pharmacology)
• Nomifensine (antagonists & inhibitors)
• Norepinephrine (physiology)
• Picolinic Acids (pharmacology)
• Rats
• Seizures (chemically induced, physiopathology)