[Combined effect of metronidazole, interferon synthesis inducers and DNA repair inhibitors].

Abstract

In experiments on mice with solid sarcoma 37, a study was made of modification of the radiosensitizing effect of metronidazole. The increase in the leucotic interferon titre, induced by the interferon synthesis inductors, did not influence the radiosensitizing efficiency of metronidazole: after the administration of the repair inhibitor, 8-bromocaffeine, the coefficient of suppression of tumor growth was higher and the number of mice with the regressed tumors greater as compared to animals affected by metronidazole and radiation.

• Authors: D L Leonidze, G G Afanas'ev, K P Khanson, L P Vartanian, A M Poverennyĭ
• Journal: Radiobiologiia (Radiobiologiia) 1986 Mar-Apr Vol. 26 Issue 2 Pg. 231-5 ISSN: 0033-8192 [Print] Russia (Federation)
• Vernacular Title: Sovmestnoe deĭstvie metronidazola, induktorov sinteza interferona i ingibitorov reparatsii DNK.
• PMID: 3704119 (Publication Type: English Abstract, Journal Article)

Chemical References

• Interferon Inducers
• Radiation-Sensitizing Agents
• xanthobine
• Metronidazole
• Caffeine

Topics

• Animals
• Caffeine (administration & dosage, analogs & derivatives, therapeutic use)
• DNA Repair (drug effects)
• Drug Synergism
• Interferon Inducers (administration & dosage, therapeutic use)
• Metronidazole (administration & dosage, therapeutic use)
• Mice
• Mice, Inbred Strains
• Radiation-Sensitizing Agents
• Sarcoma 37 (radiotherapy)
• Sarcoma, Experimental (radiotherapy)