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Antitumor activity on line 10 hepatoma in strain 2 guinea pigs and pharmaceutical properties of quinonyl-MDP preparations.

Abstract
The pharmaceutical properties of quinonyl-MDP-66 were discussed with special reference to the stability of oil-in-water emulsion, distribution capacity into regional lymph nodes and tumor regressive activity. The oil-in-water emulsion of quinonyl-MDP-66, which was prepared by treatment of quinonyl-MDP-66 with squalane (25 x) and emulsified with aqueous solution of 5% HCO-60 and 5.6% d-mannitol, was kept in lyophylized state and used after reconstitution by the addition of water before use. The reconstituted suspension of quinonyl-MDP-66 in oil-in-water emulsion was stable for more than 24 hrs. The oil-in-water emulsion of quinonyl-MDP-66 as prepared above was effective for the distribution of quinonyl-MDP-66 into regional lymph node in rats and for the regression of line 10 hepatoma in strain 2 guinea pigs by intralesional injection.
AuthorsI Azuma, Y Ogawa, Y Igari, S Ukei, Y Yamamura
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 8 Issue 1 Pg. 15-8 (Jan 1986) ISSN: 0379-0355 [Print] Spain
PMID3702541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Pharmaceutic
  • Antineoplastic Agents
  • Emulsions
  • Acetylmuramyl-Alanyl-Isoglutamine
  • quinonyl-MDP-66
Topics
  • Acetylmuramyl-Alanyl-Isoglutamine (analogs & derivatives, metabolism, pharmacology)
  • Adjuvants, Pharmaceutic (metabolism, pharmacology)
  • Animals
  • Antineoplastic Agents (metabolism, pharmacology)
  • Cell Line
  • Chemical Phenomena
  • Chemistry
  • Emulsions
  • Female
  • Guinea Pigs
  • Liver Neoplasms, Experimental (metabolism, pathology)
  • Lymph Nodes (metabolism)
  • Male
  • Neoplasm Transplantation
  • Time Factors

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