Bioinspired Structure Regulation of Apyrase-Like Nanozyme with Intracellular-Generated H2O2 for Tumor Catalytic Therapy.

Abstract

Adenosine triphosphate (ATP) is the major resource of energy supply in tumor activity. Therefore, improving ATP consumption efficiencies is a promising approach for cancer therapy. Herein, inspired by the H2O2-involved structure regulation effect during the catalysis of natural protein enzymes, we developed an artificial H2O2-driven ATP catalysis-promoting system, the Ce-based metal-organic framework (Ce-MOF), for catalytic cancer therapy. In the presence of H2O2, the hydrolysis ATP activity of Ce-MOF(H2O2) was enhanced by around 1.6 times. Taking advantage of the endogenous H2O2 in cancerous cells, catalytic hydrolysis for intracellular ATP of the Ce-MOF achieves the inhibition of cancerous cell growth, which involves damaged mitochondrial function and autophagy-associated cell death. Furthermore, in vivo studies suggest that the Ce-MOF has a good tumor inhibition effect. The artificial H2O2-driven ATP catalysis-promoting system not only demonstrates high catalytic ATP consumption efficiencies for cancer therapy but also highlights a bioinspired strategy to expedite nanozyme research in both design and applied sciences.

• Authors: Yadong Zhe, Wang Zhang, Chaoyue Gu, Lu Sun, Fangdi Dong, Zhiqiang Zhao, Kai Li, Yuqing Lin
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 15 Issue 15 Pg. 19178-19189 (Apr 19 2023) ISSN: 1944-8252 [Electronic] United States
• PMID: 37023051 (Publication Type: Journal Article)

Chemical References

• Apyrase
• Hydrogen Peroxide
• Metal-Organic Frameworks
• Adenosine Triphosphate

Topics

• Apyrase
• Hydrogen Peroxide (chemistry)
• Metal-Organic Frameworks (pharmacology, chemistry)
• Catalysis
• Adenosine Triphosphate (chemistry)