Different autochthonous models of colorectal cancer in the rat.

Abstract

Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-methylamine (AMMN) which are used worldwide for etiological and therapy studies of colon cancer are compared for tumor biology and clinical relevance. The four tumor models of colon carcinoma described in the rat are different in growth, invasion, and metastases. The choice of the selected tumor model for experimental investigations of colon cancer should depend on the clinical question.

• Authors: H Amberger
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 111 Issue 2 Pg. 157-9 ( 1986) ISSN: 0171-5216 [Print] Germany
• PMID: 3700460 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dimethylhydrazines
• Methylnitronitrosoguanidine
• methyl(acetoxymethyl)nitrosamine
• Methylnitrosourea
• 1,2-Dimethylhydrazine
• Dimethylnitrosamine

Topics

• 1,2-Dimethylhydrazine
• Adenocarcinoma (chemically induced)
• Animals
• Colonic Neoplasms (chemically induced)
• Dimethylhydrazines
• Dimethylnitrosamine (analogs & derivatives)
• Disease Models, Animal
• Methylnitronitrosoguanidine
• Methylnitrosourea
• Rats
• Rectal Neoplasms (chemically induced)