Prevention of postmetrizamide myelographic seizures in dogs, using 5% dextrose solution.

Abstract

Diuresis by IV administration of 5% dextrose in a balanced electrolyte solution (BES) reduced the frequency of occurrence of postmyelographic seizures in dogs. In the first study, a single myelogram was obtained in 8 dogs without dextrose diuresis. Two of these dogs weighed greater than 15 kg and both had seizures after metrizamide myelography. The remaining 6 dogs weighed less than 15 kg and only 2 had seizures. Greater body weight may have increased the risk of postmyelographic convulsions. In a crossover study, myelograms were obtained in 12 dogs weighing 20 to 31 kg. Six dogs were given 5% dextrose in BES (20 ml/kg of body weight/hr [diuresed]) and 6 were given BES alone (10 ml/kg/hr [not diuresed]). When myelography was repeated 10 days later, the 6 dogs that had been given 5% dextrose in BES were given BES only and the 6 dogs that had been given BES alone were given 5% dextrose in BES. The frequency of convulsions after metrizamide myelography was lower when dogs were given dextrose (33%) than when they were not (100%).

• Authors: P M Tamas, M A Walker, R R Paddleford, S R Tinkel
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 188 Issue 7 Pg. 710-2 (Apr 01 1986) ISSN: 0003-1488 [Print] United States
• PMID: 3700226 (Publication Type: Journal Article)

Chemical References

• Glucose
• Metrizamide

Topics

• Animals
• Diuresis (drug effects)
• Dog Diseases (chemically induced, prevention & control)
• Dogs
• Female
• Glucose (administration & dosage, therapeutic use)
• Male
• Metrizamide (adverse effects)
• Myelography (adverse effects, veterinary)
• Seizures (chemically induced, prevention & control, veterinary)