Hyperglycemic activity in dogs of recombinant DNA-derived 20,000 dalton variant of methionyl human growth hormone.

Abstract

The recombinant DNA-derived 20,000-dalton variant of N-terminal methionyl human growth hormone (20K-Met-hGH) had a hyperglycemic effect in fasted dogs when injected 11 hours prior to an oral glucose tolerance test (OGTT). These results reported here suggest that 20K-Met-hGH can induce glucose intolerance in dogs similar to that produced by recombinant DNA-derived 22,000 dalton N-terminal methionyl human growth hormone (22K-Met-hGH) and the normal pituitary-source human growth hormone (22K-hGH).

• Authors: C J Shaar, E L Grinnan, W G Short, J G Powell, N Bryan, K G Bemis, F C Tinsley
• Journal: Endocrine research (Endocr Res) Vol. 12 Issue 1 Pg. 21-35 ( 1986) ISSN: 0743-5800 [Print] England
• PMID: 3698925 (Publication Type: Journal Article)

Chemical References

• Recombinant Proteins
• Growth Hormone

Topics

• Amino Acid Sequence
• Animals
• Dogs
• Female
• Glucose Tolerance Test
• Growth Hormone (pharmacology)
• Hyperglycemia (chemically induced)
• Molecular Weight
• Recombinant Proteins (pharmacology)
• Time Factors