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One-day treatment of vulvovaginal candidiasis with a 500-mg clotrimazole vaginal tablet compared with a three-day regimen of two 100-mg vaginal tablets daily.

Abstract
In a randomized, double-blind trial, the efficacy and safety of a new single-dose clotrimazole vaginal tablet were compared with that of three-day clotrimazole therapy. Forty-two patients with clinically and mycologically confirmed vulvo-vaginal candidiasis received either one 500-mg clotrimazole tablet for one day or two 100-mg tablets daily for three days. Follow-up visits were performed approximately one week and one month after treatment. Thirty-six patients were evaluated for drug efficacy. There was no significant difference in clinical and mycological responses to the two regimens (P = 1.00, Fisher's exact test). At the final visit, 16 (89%) of the 18 patients receiving one-day treatment showed mycological and clinical clearance of infection, as compared to 15 (83%) of the 18 patients receiving three-day therapy. One patient in the three-day treatment group presented moderate edema of the vulva which was judged to be remotely related to treatment. The findings indicate that a single 500-mg tablet of clotrimazole is as effective and safe in the treatment of vulvovaginal candidiasis as a three-day course of 200 mg/day.
AuthorsR Floyd Jr, C Hodgson
JournalClinical therapeutics (Clin Ther) Vol. 8 Issue 2 Pg. 181-6 ( 1986) ISSN: 0149-2918 [Print] United States
PMID3698065 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Imidazoles
  • Clotrimazole
Topics
  • Adult
  • Candidiasis, Vulvovaginal (drug therapy)
  • Clotrimazole (administration & dosage, adverse effects, therapeutic use)
  • Drug Administration Schedule
  • Female
  • Humans
  • Imidazoles (administration & dosage)
  • Middle Aged
  • Random Allocation

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