Genotoxicity studies of benz[l]aceanthrylene.

Abstract

The genotoxicity of the cyclopenta-fused polycyclic aromatic hydrocarbon, benz[l]aceanthrylene (B[l]A), was evaluated in vitro using the L5178Y/TK+/- mouse lymphoma assay and in vivo using the mouse peripheral blood lymphocyte (PBL) culture system. The mutagenicity and sister chromatid exchange (SCE) inducing potential of B[l]A was then compared to that of benzo[a]pyrene (B[a]P). B[l]A appeared to be slightly less mutagenic than B[a]P at the TK locus, and each compound produced both small and large colony mutants indicating that they are clastogenic as well as mutagenic. Gross chromosome aberration analysis of treated L5178Y/TK+/- mouse lymphoma cells confirmed the clastogenicity of B[l]A in vitro. In the mouse PBL system, after administration by gavage, B[l]A was more cytotoxic and produced a sharper elevation in SCE frequency than B[a]P.

• Authors: A D Kligerman, M M Moore, G L Erexson, K H Brock, C L Doerr, J W Allen, S Nesnow
• Journal: Cancer letters (Cancer Lett) Vol. 31 Issue 2 Pg. 123-31 (May 1986) ISSN: 0304-3835 [Print] Ireland
• PMID: 3697957 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Benz(a)Anthracenes
• Mutagens
• Benzo(a)pyrene
• benz(l)aceanthrylene
• Thymidine Kinase

Topics

• Animals
• Benz(a)Anthracenes (toxicity)
• Benzo(a)pyrene (toxicity)
• Cell Line
• Cell Survival (drug effects)
• Chromosome Aberrations (drug effects)
• Leukemia L5178 (genetics, pathology)
• Lymphocytes (cytology, ultrastructure)
• Male
• Mice
• Mice, Inbred C57BL
• Mitosis (drug effects)
• Mutagenicity Tests
• Mutagens
• Mutation
• Sister Chromatid Exchange (drug effects)
• Thymidine Kinase (genetics)