Exploring state-of-the-art advances in targeted nanomedicines for managing acute and chronic inflammatory lung diseases.

Abstract

Diagnosis and treatment of lung diseases pose serious challenges. Currently, diagnostic as well as therapeutic methods show poor efficacy toward drug-resistant bacterial infections, while chemotherapy causes toxicity and nonspecific delivery of drugs. Advanced treatment methods that cure lung-related diseases, by enabling drug bioavailability via nasal passages during mucosal formation, which interferes with drug penetration to targeted sites, are in demand. Nanotechnology confers several advantages. Currently, different nanoparticles, or their combinations, are being used to enhance targeted drug delivery. Nanomedicine, a combination of nanoparticles and therapeutic agents, that delivers drugs to targeted sites increases the bioavailability of drugs at these sites. Thus, nanotechnology is superior to conventional chemotherapeutic strategies. Here, the authors review the latest advancements in nanomedicine-based drug-delivery methods for managing acute and chronic inflammatory lung diseases.

• Authors: Sujata Maurya, Rashi Srivastava, Saniya Arfin, Susan Hawthorne, Niraj Kumar Jha, Kirti Agrawal, Sibi Raj, Brijesh Rathi, Arun Kumar, Riya Raj, Sharad Agrawal, Ana Cláudia Paiva-Santos, Asrar Ahmad Malik, Kamal Dua, Rakesh Rana, Shreesh Ojha, Saurabh Kumar Jha, Ankur Sharma, Dhruv Kumar, Sally A El-Zahaby, Amka Nagar
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 17 Issue 30 Pg. 2245-2264 (12 2022) ISSN: 1748-6963 [Electronic] England
• PMID: 36975758 (Publication Type: Journal Article, Review)

Chemical References

• Pharmaceutical Preparations

Topics

• Humans
• Nanomedicine (methods)
• Drug Delivery Systems (methods)
• Nanotechnology (methods)
• Pharmaceutical Preparations
• Lung
• Lung Diseases (drug therapy)
• Nanoparticles