A circulating hypertensive factor in primary hypertension: effect of antihypertensive therapy.

Abstract

In this study the role of a humoral hypertensive factor in spontaneously hypertensive rats (SHR) of the Münster strain was examined by cross-circulation. It was demonstrated that hypertension of the SHR could be transmitted to cross-circulation normotensive Wistar-Kyoto rats. The results led to the following conclusion: primary hypertension is caused by a circulating factor which is produced by kidneys and adrenals and suppressed by acute volume depletion and chronic dietary salt restriction. The antihypertensive effect of nifedipine probably leads to a compensatory stimulation of the hypertensive factor in SHR.

• Authors: U Heckmann, E Ottens, W Zidek, H Vetter
• Journal: Nephron (Nephron) Vol. 47 Suppl 1 Pg. 138-41 ( 1987) ISSN: 1660-8151 [Print] Switzerland
• PMID: 3696343 (Publication Type: Journal Article)

Chemical References

• Blood Proteins
• Nifedipine

Topics

• Adrenalectomy
• Animals
• Blood Proteins (metabolism)
• Cross Circulation
• Hypertension (blood, drug therapy)
• Male
• Nephrectomy
• Nifedipine (therapeutic use)
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY