Factors associated with survival in patients with lymphoma and HIV.

Abstract

OBJECTIVE:

To analyze the factors associated with survival in the largest cohort of individuals with HIV and lymphoma so far described in Brazil.

DESIGN:

A retrospective, observational, multicenter study involving five institutions in São Paulo, Brazil.

METHODS:

The medical records of consecutive patients with HIV diagnosed with lymphoma between January 2000 and December 2019 were screened. Inclusion criteria consisted of age over 17 years and a biopsy-confirmed diagnosis of lymphoma. The data collected included age, sex, staging (Ann Arbor system), duration of HIV infection, CD4 + lymphocyte count, HIV viral load, lactate dehydrogenase, erythrocyte sedimentation rate and serum beta-2-microglobulin levels, treatment and outcome.

RESULTS:

Overall, 276 patients were included. Median age was 42 years. Most patients were male (74.3%) and with an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (28.6% and 46.4%, respectively). Most had non-Hodgkin lymphomas (89.2%, n  = 246), particularly diffuse large B-cell lymphoma (40.9%) and Burkitt lymphoma (26.4%). Hodgkin lymphoma accounted for 9.4%. Advanced stages III/IV were predominant (86.8%). HIV viral load at the moment of lymphoma diagnosis was detectable in 52.9% of patients. A CD4 + cell count of <200 cells/μl was recorded for 53% of the patients. Most patients (62.4%) were on combination antiretroviral therapy. The factors that significantly affected survival were: the ECOG performance status, lymphoma subtype, staging, beta-2-microglobulin level, central nervous system (CNS) infiltration, site of CNS infiltration, relapsed/refractory lymphoma and International Prognostic Index score.

CONCLUSIONS:

HIV status, CD4 + -lymphocyte count and relapsed/refractory disease affected survival. Rituximab did not appear to improve outcome in HIV-related lymphomas.

• Authors: Juliano Cordova Vargas, Mariana de Oliveira Marques, Juliana Pereira, Walter M Tobias Braga, Nelson Hamerschlak, Jacques Tabacof, Paulo Roberto Abrão Ferreira, Gisele W Braga Colleoni, Otavio C G Baiocchi
• Journal: AIDS (London, England) (AIDS) Vol. 37 Issue 8 Pg. 1217-1226 (07 01 2023) ISSN: 1473-5571 [Electronic] England
• PMID: 36939075 (Publication Type: Multicenter Study, Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Topics

• Humans
• Male
• Adult
• Adolescent
• Female
• HIV Infections (drug therapy, complications)
• Retrospective Studies
• Brazil (epidemiology)
• Lymphoma, Non-Hodgkin
• Lymphoma, Large B-Cell, Diffuse (drug therapy)
• Lymphoma, AIDS-Related (drug therapy, complications)
• Prognosis
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)