HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Single-dose pharmacokinetics of factor IX evaluated by model-independent methods.

Abstract
We studied the pharmacokinetic data of 13 subjects with hemophilia B treated with a single-dose of a Factor IX concentrate (Bebulin TIM2, N = 9; Preconativ, N = 4). The decay curves of Factor IX were evaluated by model-independent methods and the following pharmacokinetic parameters (mean +/- SD) were estimated: clearance (ml/h/kg) = 4.99 +/- 2.01; mean residence time (h) = 22.9 +/- 10.6; volume of distribution (ml/kg) = 99.9 +/- 35.5. The in vivo recovery (59.8% +/- 16.9%) was found to be inversely correlated with the volume of distribution. No significant difference in the pharmacokinetic parameters was found between patients treated with Preconativ and those treated with Bebulin. A model-dependent compartmental evaluation of the 13 decay curves showed that the two-compartment model was better than the one-compartment model in 7 cases (53.8%), but the improvement of fit resulting from the two-compartment model was statistically significant in only 2 cases (15.4%).
AuthorsG Longo, S Cinotti, E Filimberti, G Giustarini, A Messori, M Morfini, P R Ferrini
JournalEuropean journal of haematology (Eur J Haematol) Vol. 39 Issue 5 Pg. 426-33 (Nov 1987) ISSN: 0902-4441 [Print] England
PMID3691761 (Publication Type: Journal Article)
Chemical References
  • Factor IX
Topics
  • Factor IX (administration & dosage, pharmacokinetics)
  • Hemophilia B (therapy)
  • Humans
  • Mathematics

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: