The Utility of Common Blood Coagulation Examination in Identifying Hemorrhoid Complications.

Abstract

BACKGROUND:

This observational study was designed to evaluate prothrombin time and activity (PT, PT%), prothrombin time international normalized ratio (INR), activated partial thromboplastin time (APTT), coagulation enzyme time (TT), fibrinogen content (FIB), D-dimer (D-dimer), and platelet count (Plt) in patients with hemorrhoids (HE, n = 207), hemorrhoids with bleeding (HB, n = 59), and incarcerated hemorrhoids (IH, n = 10) and the utility of these parameters in the differential diagnosis of hemorrhoids with thrombosis (HT, n = 30).

METHODS:

Patients were grouped according to the relevant clinical diagnosis and classification standards. Blood coagulation-related tests, platelet counts, and relevant laboratory indicators (PT%, PT, APTT, TT, INR, FIB, D-dimer, and Plt) were carried out with samples obtained from patients with hemorrhoids.

RESULTS:

In the ROC curve analysis, D-dimer could better distinguish HE from HB (AUC = 0.587, p = 0.042). D-dimer (AUC = 0.643, p = 0.011), INR (AUC = 0.630, p = 0.022), and TT (AUC = 0.617, p = 0.038) could distinguish HT from HE, although no significant difference was observed between the ROC curves.

CONCLUSIONS:

D-dimer is useful in distinguishing HE from HB. Moreover, D-dimer, INR, and TT are useful in distinguishing HE from HT. Our findings provide a theoretical basis for future research in this area.

• Authors: Fangchao Mei, Hui Cheng, Maowen Huang, Hongyan Zhao
• Journal: Clinical laboratory (Clin Lab) Vol. 69 Issue 3 (Mar 01 2023) ISSN: 1433-6510 [Print] Germany
• PMID: 36912309 (Publication Type: Observational Study, Journal Article)

Topics

• Humans
• Hemorrhoids
• Blood Coagulation
• Blood Coagulation Tests
• Prothrombin Time
• Partial Thromboplastin Time