Abstract | OBJECTIVES: METHODS: Twenty-one patients with hospital-acquired CNS infections caused by CRKP who received treatment with CZA for ≥ 72 hours were enrolled. The primary outcome was to assess the clinical and microbiology efficacy of CZA for the treatment of CNS infections caused by CRKP. RESULTS: A high burden of comorbidity was discovered in 20 of 21 patients (95.2%). Most patients had a history of craniocerebral surgery and 17 (81.0%) of the patients were in the intensive care unit with a median APACHE II score of 16 (IQR 9-20) and SOFA score of 6 (IQR 3-7). Eighteen cases were treated by CZA-based combination therapies, while the remaining three cases were treated with CZA alone. At the end of the treatment, the overall clinical efficacy was 76.2% (16 of 21) with a bacterial clearance rate of 81.0% (17 of 21) and all-cause mortality of 23.8% (five of 21). CONCLUSION: This study showed that CZA-based combination therapy is an effective treatment option for CNS infections caused by CRKP.
|
Authors | Xiaoyu Zhao, Shirong Li, Yixin Zhang, Jue Wang, Chuning Wang, Xiaohua Qin, Fupin Hu, Minggui Wang |
Journal | International journal of antimicrobial agents
(Int J Antimicrob Agents)
Vol. 61
Issue 5
Pg. 106777
(May 2023)
ISSN: 1872-7913 [Electronic] Netherlands |
PMID | 36905946
(Publication Type: Journal Article)
|
Copyright | Copyright © 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved. |
Chemical References |
- avibactam, ceftazidime drug combination
- Ceftazidime
- Anti-Bacterial Agents
- Azabicyclo Compounds
- Drug Combinations
- Carbapenems
|
Topics |
- Humans
- Klebsiella pneumoniae
- Retrospective Studies
- Klebsiella Infections
(microbiology)
- Ceftazidime
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Azabicyclo Compounds
(therapeutic use)
- Drug Combinations
- Carbapenems
(therapeutic use)
- Carbapenem-Resistant Enterobacteriaceae
- Central Nervous System Infections
(drug therapy)
- Hospitals
- Microbial Sensitivity Tests
|