Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia.

Abstract

Recent reports of in vivo antagonism of the acute anti-conflict, ataxic, and lethal effects of ethanol with the partial inverse agonist imidazobenzodiazepine Ro15-4513 implicate the GABAa/benzodiazepine receptor in mediating several acute effects of ethanol. These data raise the question as to whether all of the acute effects of ethanol can be antagonized by Ro15-4513. The present study addressed this issue by investigating the effect of Ro15-4513 on ethanol-induced loss of righting reflex and hypothermia in mice. We found that Ro15-4513 antagonized the hypnotic, but not the hypothermic, effects of ethanol when tested under identical conditions. These results suggest that the GABAa/benzodiazepine receptor may not be involved in mediating all pharmacological effects of ethanol.

• Authors: P J Syapin, K W Gee, R L Alkana
• Journal: Brain research bulletin (Brain Res Bull) Vol. 19 Issue 5 Pg. 603-5 (Nov 1987) ISSN: 0361-9230 [Print] United States
• PMID: 3690369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Azides
• Hypnotics and Sedatives
• Benzodiazepines
• Ethanol
• Ro 15-4513

Topics

• Animals
• Azides (pharmacology)
• Benzodiazepines (pharmacology)
• Body Temperature (drug effects)
• Ethanol (antagonists & inhibitors, pharmacology)
• Hypnotics and Sedatives (antagonists & inhibitors, pharmacology)
• Hypothermia (chemically induced, physiopathology)
• Male
• Mice
• Mice, Inbred C57BL
• Sleep (drug effects)
• Time Factors