[Prevention, using alpha-tocopherol and lidocaine, of damage to the monooxygenase system activity and ultrastructure of hepatocytes following acute ischemia of the liver].

Abstract

The experiments on rats have shown that alpha-tocopherol and lidocaine pretreatment leads to a decrease in the level of ischemic cell necrosis in the liver. The volume of cell necrosis in the liver was significantly decreased (more than threefold) in the case of drug pretreatment. The combination of alpha-tocopherol with lidocaine fully prevented the decrease in N-dimethylation of amidopyrine and cytochrome P-450 and b5 concentration, and the development of destructive alterations of cytoplasmic reticulum in the unaffected rat hepatocytes. alpha-Tocopherol and lidocaine pretreatment was effective for the retention of the depression of microsomal monooxygenases by phenobarbital in remote periods after acute hepatic ischemia.

• Authors: O R Grek, V I Sharapov, I A Sokirchenko, V A Shkurupiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 104 Issue 12 Pg. 669-71 (Dec 1987) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Profilaktika al'fa-tokoferolom i lidokainom narusheniĭ aktivnosti monooksigenaznoĭ sistemy i ul'trastruktury gepatitsitov posle ostroĭ ishemii pecheni.
• PMID: 3689956 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vitamin E
• Lidocaine
• Oxygenases

Topics

• Acute Disease
• Animals
• Ischemia (drug therapy, enzymology, pathology)
• Lidocaine (therapeutic use)
• Liver (blood supply, enzymology, ultrastructure)
• Male
• Oxygenases (metabolism)
• Rats
• Vitamin E (therapeutic use)