Roles of kallikrein-kinin system in acute inflammation: studies on high- and low-molecular weight kininogens-deficient rats (B/N-Katholiek strain).

Abstract

Carrageenin-induced paw edema in HMW- and LMW-kininogens-deficient rats was significantly less than that in normal rats. There are three kininogens, HMW-, LMW- and T-kininogens, in normal rat plasma, but B/N-Katholiek rat plasma contains only T-kininogen. The pretreatment with captopril, a kiniase II inhibitor, enhanced paw swelling of normal rats, but not that of the deficient rats, indicating that bradykinin released from HMW-kininogen may have a role for the swelling but T-kinin may not be released in this inflammation.

• Authors: S Oh-ishi, I Hayashi, I Utsunomiya, M Hayashi, K Yamaki, A Yamasu, T Nakano
• Journal: Agents and actions (Agents Actions) Vol. 21 Issue 3-4 Pg. 384-6 (Aug 1987) ISSN: 0065-4299 [Print] Switzerland
• PMID: 3687591 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Kininogens
• Kinins
• Kallikreins

Topics

• Animals
• Inflammation (blood, etiology)
• Kallikreins (blood)
• Kininogens (blood, deficiency)
• Kinins (blood)
• Male
• Rats
• Rats, Inbred BN