HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Coronary artery involvement in Kawasaki syndrome in Manhattan, New York: risk factors and role of aspirin.

Abstract
Since January 1980, 110 children having 113 attacks of Kawasaki syndrome were studied. Age at onset was 7 weeks to 12 years (mean 3 6/12 years, median 2 9/12 years); 77% were younger than 5 years of age; the male to female ratio was 1.8; racial distribution was 52% white, 19% black, 14% Hispanic, and 16% Asian. Protocol of management consisted of high-dose aspirin (100 mg/kg/d) until afebrile, and then 81 mg every day until free of coronary aneurysm. Two-dimensional echocardiograms were done weekly during the acute stage, at 2 and 6 months after onset, and yearly if a coronary abnormality was detected. At 1 month, 51 coronary arterial abnormalities were present in 25 patients. Risk factors for a coronary abnormality were duration of fever greater than or equal to 2 weeks, level of platelet count, marked elevation of ESR, and age younger than 5 years. No statistically significant difference in incidence of aneurysms was detected between patients on high-dose aspirin and those on medium-or low-dose aspirin.
AuthorsF Ichida, N S Fatica, M A Engle, J E O'Loughlin, A A Klein, M S Snyder, K H Ehlers, A R Levin
JournalPediatrics (Pediatrics) Vol. 80 Issue 6 Pg. 828-35 (Dec 1987) ISSN: 0031-4005 [Print] UNITED STATES
PMID3684392 (Publication Type: Journal Article)
Chemical References
  • Aspirin
Topics
  • Aspirin (administration & dosage, therapeutic use)
  • Child
  • Child, Preschool
  • Coronary Aneurysm (etiology, prevention & control)
  • Female
  • Humans
  • Infant
  • Male
  • Mucocutaneous Lymph Node Syndrome (complications, drug therapy)
  • New York
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: