Abstract |
Forty-two outpatients with major depressive disorder were treated with oral fezolamine in a 6-week, three-center open-label study. Therapy was initiated at 100 mg/day; thereafter dosage was increased based on the response of the patient. Maintenance dosage usually ranged between 100 and 450 mg/day. Clinically significant improvement relative to the patient's prestudy state was observed after 2 weeks in both patient and physician-rating scales. Fifty-five percent of patients improved their Hamilton Psychiatric Rating Scale for Depression (HAM-D) scores by more than 50%. The median dose associated with a clinically significant response was 245 mg/day. Five of the 6 patients who dropped out did so because of gastrointestinal adverse effects. The most common adverse effects were nausea (36%), headache (29%), constipation (26%), and dry mouth (24%).
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Authors | S Zisook, J Mendels, D Janowsky, J Feighner, J C Lee, A Fritz |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 17
Issue 3
Pg. 133-8
( 1987)
ISSN: 0302-282X [Print] Switzerland |
PMID | 3683802
(Publication Type: Journal Article)
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Chemical References |
- Antidepressive Agents
- Pyrazoles
- fezolamine
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Topics |
- Adult
- Antidepressive Agents
(therapeutic use)
- Depressive Disorder
(drug therapy, psychology)
- Female
- Humans
- Male
- Pilot Projects
- Psychiatric Status Rating Scales
- Pyrazoles
(adverse effects, therapeutic use)
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