MTP-1307, a novel antidiabetic agent, improves the glucose intolerance of viable yellow obese-diabetic mice.

Abstract

MTP-1307 is an oral antidiabetic agent with a unique profile. It improves the glucose intolerance of viable yellow obese-diabetic mice at 25 mg/kg whereas at 300 mg/kg, it only marginally lowers the basal glucose levels of the same mice. This selective activity on exogenous glucose makes MTP-1307 potentially a useful agent to treat postprandial glucose intolerance without causing hypoglycemia.

• Authors: T T Yen
• Journal: Life sciences (Life Sci) Vol. 41 Issue 21 Pg. 2349-54 (Nov 23 1987) ISSN: 0024-3205 [Print] Netherlands
• PMID: 3683081 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Pyrimidines
• MTP 1307
• Tolbutamide

Topics

• Animals
• Blood Glucose (metabolism)
• Diabetes Mellitus (blood, drug therapy)
• Diabetes Mellitus, Experimental (blood, drug therapy)
• Fasting
• Glucose Tolerance Test
• Hypoglycemic Agents (therapeutic use)
• Kinetics
• Male
• Mice
• Mice, Inbred Strains
• Mice, Mutant Strains
• Obesity
• Pyrimidines (therapeutic use)
• Tolbutamide (therapeutic use)