[Clinical study of astromicin administered by intravenous drip infusion against chronic complicated urinary tract infections].

Abstract

Astromicin (ASTM) was administered by intravenous drip infusion (i.v.d.) to 22 patients with chronic complicated urinary tract infections and the clinical efficacy and safety of this drug were evaluated. The overall clinical efficacy rate obtained was 71.4% (excellent 6; moderate 9) of 21 evaluable cases by the UTI committee's criteria. Concerning the response on clinical isolates, the drug was highly effective especially against strains of Escherichia coli, indole positive Proteus and Serratia marcescens. It was not effective, however, against 2 strains of Pseudomonas aeruginosa. As for adverse reactions, there was one case which complained of headache on the 3rd day after starting treatment. In this case the drug administration was discontinued at the 5th day. The symptom disappeared within 24 hours without any treatment. No any other adverse reactions were noted. With regard to clinical test values for peripheral blood, liver and renal functions, no abnormality was observed in any of the cases treated with the drug. In conclusion, ASTM was found to be a highly effective and safe drug when administered by intravenous drip infusion in the treatment of chronic complicated urinary tract infections.

• Authors: K Suzuki, K Takanashi, I Nagakubo, H Kiyosaki, Y Naide
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 40 Issue 7 Pg. 1299-310 (Jul 1987) ISSN: 0368-2781 [Print] Japan
• PMID: 3682183 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• fortimicin A

Topics

• Adult
• Aged
• Aged, 80 and over
• Aminoglycosides
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Bacterial Infections (drug therapy, etiology)
• Chronic Disease
• Female
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Urinary Tract Infections (drug therapy, etiology)