Correlation of plasma adipokines with endometrial atypical hyperplasia and type I/II endometrial cancer.
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| Abstract |
The aim of the study was to systematically explore the relationships between various adipokines and risks of endometrial atypical hyperplasia (EAH), type I endometrial cancer (EC), and type II EC. We enrolled 219 patients in this study, including 39 EAH, 87 type I EC, 38 type II EC and 55 control individuals. We subsequently explored the association of adipokine levels and the leptin-to-adiponectin (L/A) ratio with EAH, type I EC, and type II EC. The plasma leptin level and L/A ratio were significantly higher in the EAH group than in the control group (p = 0.012). Leptin, resistin, vaspin, and visfatin levels were significantly higher in the type I EC group; however, the adiponectin level was lower in the type I EC, which resulted in a higher L/A ratio. Notably, the L/A ratio and visfatin level in the type II EC group were significantly higher. Multiple logistic regression analysis revealed that a higher leptin level was significantly associated with a higher EAH risk (p = 0.012). Higher leptin level (p = 0.042) and L/A ratio (p = 0.027) were significantly associated with an increased type I EC risk. By contrast, higher leptin (p = 0.059) and visfatin (p = 0.003) levels, higher L/A ratio (p = 0.033), and lower adiponectin level (p = 0.042) were associated with an increased type II EC risk. We suggested that adipokines are potentially correlated with EAH and EC risks.
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| Authors | Xinxin Zhu, Linzhi Liu, Zonghao Feng, Yan Zhang |
| Journal | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (J Obstet Gynaecol) Vol. 43 Issue 1 Pg. 2179914 (Dec 2023) ISSN: 1364-6893 [Electronic] England |
| PMID | 36815556 (Publication Type: Journal Article) |
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