Drug cytotoxicity at elevated temperature. In vitro study on the U-87MG glioma cell line.

Abstract

The malignant glioma cell line U-87MG was used for 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), aziridinylbenzoquinone (AZQ), cis-diaminodichloroplatinum (II) (cis-DDP), and spirohydantoin mustard (SHM) treatments at 37 degrees and 42 degrees C. With the exception of SHM, all drugs killed a greater proportion of cells at the higher temperature, as assessed by the colony-formation assay. Drug-dose enhancement ratios were 1.6, 2.8, 2, and 1:1 for BCNU, AZQ, cis-DDP, and SHM, respectively. Because methods to heat discrete volumes of brain are now available, we conclude that hyperthermic increase of BCNU, AZQ, and cis-DDP cytotoxicity might have therapeutic application for malignant gliomas.

• Authors: V F Da Silva, G P Raaphorst, R Goyal, M Feeley
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 67 Issue 6 Pg. 885-8 (Dec 1987) ISSN: 0022-3085 [Print] United States
• PMID: 3681426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Aziridines
• Benzoquinones
• Cyclohexenes
• Hydantoins
• Nitrogen Mustard Compounds
• 2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone
• spiromustine
• Cisplatin
• Carmustine

Topics

• Antineoplastic Agents (administration & dosage)
• Aziridines (administration & dosage)
• Benzoquinones
• Brain Neoplasms (drug therapy)
• Carmustine (administration & dosage)
• Cell Line
• Cisplatin (administration & dosage)
• Cyclohexenes
• Glioma (drug therapy)
• Hot Temperature (therapeutic use)
• Humans
• Hydantoins (administration & dosage)
• In Vitro Techniques
• Nitrogen Mustard Compounds (administration & dosage)