Lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine-related compounds and their formation in rats.

Abstract

Lung carcinogenesis by a single intraperitoneal injection of N-nitrosobis(2-hydroxypropyl)amine (NDHPA) and related compounds was studied in male Wistar rats. NDHPA, N-nitrosomethyl(2-hydroxypropyl)amine (NMHPA), N-nitrosobis(2-oxopropyl)amine (NDOPA), N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (NHPOPA) and N-nitroso-2,6-dimethylmorpholine (NDMMOR) induced high incidences of lung neoplasms in rats. The formation of NDHPA, NDMMOR and NMHPA in the stomach of rats treated with precursor amines and sodium nitrite was detected by high-performance liquid chromatography (HPLC).

• Authors: Y Konishi, Y Yokose, Y Mori, H Yamazaki, K Yamamoto, A Nakajima, A Denda
• Journal: IARC scientific publications (IARC Sci Publ) Issue 84 Pg. 250-2 ( 1987) ISSN: 0300-5038 [Print] France
• PMID: 3679377 (Publication Type: Journal Article)

Chemical References

• Nitrosamines
• diisopropanolnitrosamine

Topics

• Animals
• Chromatography, High Pressure Liquid
• Lung Neoplasms (chemically induced)
• Male
• Nitrosamines
• Rats
• Rats, Inbred Strains