Effect of ascorbic acid on the metabolism of N-nitrosopiperidine.

Abstract

Guinea-pigs were fed diets containing 48, 200 or 2000 mg/kg ascorbic acid (AsA) for 20-30 days and given a single oral dose of 50 mg N-nitrosopiperidine (NPIP)/kg body weight. The levels of glutaric acid, 3-hydroxy-NPIP and 4-hydroxy-NPIP, but not of 1,5-pentanediol, in urine increased with the dose of AsA in the diet.

• Authors: M Nakamura, Y Osada, Y Horiguchi, T Nakaoka, K Ito, T Kawabata
• Journal: IARC scientific publications (IARC Sci Publ) Issue 84 Pg. 173-4 ( 1987) ISSN: 0300-5038 [Print] France
• PMID: 3679363 (Publication Type: Journal Article)

Chemical References

• Nitrosamines
• N-nitrosopiperidine
• Ascorbic Acid

Topics

• Animals
• Ascorbic Acid (pharmacology)
• Diet
• Guinea Pigs
• Nitrosamines (metabolism, urine)