Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration.

Abstract	The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.
Authors	E Barbieri, R Latini, V D'Aranno, A Fabbri, P Zampieri, G P Trevi, P Zardini
Journal	Clinical cardiology (Clin Cardiol) Vol. 10 Issue 11 Pg. 674-6 (Nov 1987) ISSN: 0160-9289 [Print] United States
PMID	3677501 (Publication Type: Case Reports, Journal Article)
Chemical References	desethylamiodarone Amiodarone
Topics	Amiodarone (administration & dosage, analogs & derivatives, pharmacokinetics) Female Humans Injections, Intravenous Male Middle Aged Myocardial Infarction (drug therapy) Tissue Distribution

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