Occurrence of circulating 7-deoxyaglycone metabolites of 4'-deoxydoxorubicin in man.

Abstract

In five cancer patients we have determined the pharmacokinetics of 4'-deoxydoxorubicin (4'-DOX), its alcoholic metabolite 4'-deoxydoxorubicinol and the occurrence of circulating 7-deoxyaglycone metabolites. The 7-deoxyaglycone of the alcohol metabolite, the major aglycone of Adriamycin (ADR) present in man, was not detected in any serum sample. The 7-deoxyaglycone of the parent drug, which appears in concentrations in excess of 30 ng/ml after ADR administration, was detected in only 2/5 patients in trace amounts. These preliminary data indicate a difference in biotransformation between ADR and 4'-DOX despite their close structural similarities.

• Authors: J Cummings, D J Kerr, S B Kaye
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 20 Issue 3 Pg. 263-4 ( 1987) ISSN: 0344-5704 [Print] Germany
• PMID: 3677300 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Naphthacenes
• adriamycin aglycone
• Doxorubicin
• 4'-deoxydoxorubicinol
• esorubicin
• 7-deoxyadriamycin aglycone

Topics

• Biotransformation
• Chromatography, High Pressure Liquid
• Doxorubicin (analogs & derivatives, blood, metabolism, pharmacokinetics, therapeutic use)
• Female
• Half-Life
• Humans
• Kidney Neoplasms (drug therapy)
• Male
• Naphthacenes (blood)