Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment.

Abstract

We assessed the efficacy of polydeoxyribonucleotide (PDRN) in accelerating the healing of diabetic wounds in a murine model of streptozotocin (STZ)-induced diabetes. After the creation of diabetic wounds, the mice of the PDRN SC, PDRN IP and PBS groups received a subcutaneous, an intra-peritoneal injection of PDRN and a subcutaneous injection of PBS, respectively. After euthanasia, time-dependent changes in the wound diameter and histologic scores were measured and vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and collagen types I and III were assessed for their expression levels. The PDRN SC and the PDRN IP groups showed a significantly smaller diameter of diabetic wounds, significantly higher histologic scores, a significantly greater expression of VEGF, a significantly lower expression of TGF-β1 and a significantly greater expression of collagen types I and III as compared with the PBS group (p < 0.05 or 0.0001). In conclusion, PDRN might be effective in promoting the healing of diabetic wounds in a murine model of STZ-induced diabetes.

• Authors: Jiyoung Yun, SaeGwang Park, Ha Young Park, Kyung Ah Lee
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 24 Issue 3 (Jan 18 2023) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 36768255 (Publication Type: Journal Article)

Chemical References

• Transforming Growth Factor beta1
• Vascular Endothelial Growth Factor A
• Streptozocin
• Polydeoxyribonucleotides
• Collagen Type I

Topics

• Mice
• Animals
• Transforming Growth Factor beta1 (genetics)
• Vascular Endothelial Growth Factor A (metabolism)
• Streptozocin
• Disease Models, Animal
• Polydeoxyribonucleotides (pharmacology, therapeutic use)
• Diabetes Mellitus, Experimental (complications, drug therapy, metabolism)
• Collagen Type I (genetics)