Acanthamoebic keratitis diagnosed by paracentesis and biopsy and treated with propamidine.

Abstract

A previously healthy 53-year-old man had keratitis of the right eye for six months, unresponsive to topical medical therapy. Acanthamoeba was grown from tissue obtained by corneal biopsy and from aqueous from an anterior chamber tap. The patient was treated with propamidine isethionate 0.1% drops and dibromopropamidine isethionate 0.15% ointment, and after two and a half months the ocular inflammation was continuing to resolve. This case supports a role for the diamidines in the treatment of acanthamoebic keratitis.

• Authors: K McClellan, D J Coster
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 71 Issue 10 Pg. 734-6 (Oct 1987) ISSN: 0007-1161 [Print] England
• PMID: 3676141 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiprotozoal Agents
• Benzamidines
• dibrompropamidine
• propamidine isethionate

Topics

• Acanthamoeba (isolation & purification)
• Amebiasis (diagnosis, drug therapy)
• Animals
• Antiprotozoal Agents (therapeutic use)
• Benzamidines (therapeutic use)
• Cornea (parasitology)
• Humans
• Keratitis (drug therapy, etiology)
• Male
• Middle Aged