RO 15-4513 induces seizures in DBA/2 mice undergoing alcohol withdrawal.

Abstract

RO 15-4513, an imidazodiazepine that has been reported to reverse some of the behavioral effects of ethanol, was given to DBA/2 mice. Although no animals treated with a 6 mg/kg dose of this drug had seizures, 20% of animals given 20 mg/kg of this drug had tonic seizures. Ethanol withdrawal was induced in DBA/2 mice treated with 4-methyl pyrazole using an inhalation paradigm. Mice were more likely to have a seizure during ethanol withdrawal if treated with RO 15-4513 (6 mg/kg) than if they received the vehicle. These data suggest administering RO 15-4513 as an alcohol antagonist to alcoholic subjects may increase the incidence of seizures.

• Authors: R G Lister, J W Karanian
• Journal: Alcohol (Fayetteville, N.Y.) (Alcohol) 1987 Sep-Oct Vol. 4 Issue 5 Pg. 409-11 ISSN: 0741-8329 [Print] United States
• PMID: 3675863 (Publication Type: Journal Article)

Chemical References

• Azides
• Benzodiazepines
• Ethanol
• Ro 15-4513

Topics

• Animals
• Azides (pharmacology)
• Benzodiazepines (pharmacology)
• Ethanol (adverse effects)
• Male
• Mice
• Mice, Inbred DBA
• Seizures (chemically induced)
• Substance Withdrawal Syndrome (metabolism)