Evaluation of oral minoxidil in the treatment of alopecia areata.

A dose-response effect has previously been demonstrated in topical minoxidil treatment of alopecia areata. Limitations in minoxidil solubility and percutaneous absorption have impaired the development of more effective topical therapy. Oral minoxidil (5 mg every 12 hours), a dose demonstrated to be relatively well tolerated if a 2-g sodium diet is strictly followed, was given to 65 patients with severe, treatment-resistant alopecia areata in an attempt to bypass the limitations of topical treatment and increase efficacy. Although hair regrowth progressed more rapidly and was more extensive with oral than topical 5% minoxidil, cosmetic response was seen only in 18% of the patients. Neither serum nor tissue levels of minoxidil correlated with response. These findings suggest that improved preparations of topical minoxidil, when used as a single therapeutic agent, are unlikely to be cosmetically effective in the majority of patients with severe alopecia areata.
AuthorsV C Fiedler-Weiss, J Rumsfield, C M Buys, D P West, A Wendrow
JournalArchives of dermatology (Arch Dermatol) Vol. 123 Issue 11 Pg. 1488-90 (Nov 1987) ISSN: 0003-987X [Print] UNITED STATES
PMID3674909 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Minoxidil
  • Administration, Oral
  • Administration, Topical
  • Adult
  • Alopecia Areata (drug therapy)
  • Dose-Response Relationship, Drug
  • Female
  • Hair (growth & development)
  • Humans
  • Male
  • Minoxidil (administration & dosage, therapeutic use)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: