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[Eremomycin--a new antibiotic from the cyclic glycopeptide group].

Abstract
Eremomycin, a novel antibiotic belonging to the group of cyclic glycopeptides is produced by an actinomycete designated INA-238. Biosynthesis, isolation, physico-chemical and biological properties of the antibiotic are described. Eremomycin is shown to be close to vancomycin. However, by its chromatographic and electrophoretic mobility, presence of chlorine in the antibiotic molecule and optic characteristics eremomycin differs from vancomycin. Eremomycin is less toxic than vancomycin whereas its chemotherapeutic activity in treatment of infections caused by gram-positive organisms is higher.
AuthorsG F Gauze, M G Brazhnikova, A V Laĭko, M A Sveshnikova, T P Preobrazhenskaia
JournalAntibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology (Antibiot Med Biotekhnol) Vol. 32 Issue 8 Pg. 571-6 (Aug 1987) ISSN: 0233-7525 [Print] Russia (Federation)
Vernacular TitleEremomitsin--novyĭ antibiotik iz gruppy tsiklicheskikh glikopeptidov.
PMID3674837 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Vancomycin
Topics
  • Animals
  • Anti-Bacterial Agents (analysis, pharmacology, toxicity)
  • Chemical Phenomena
  • Chemistry, Physical
  • Fermentation
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Weight
  • Structure-Activity Relationship
  • Vancomycin (analysis, pharmacology, toxicity)

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