Excess HLA antigens after transfusion of sickle cell patient with AIDS.

Abstract

A woman with sickle cell-hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA-A and DR antigens (triplets) on her circulating lymphocytes. Three of her first-degree relatives were HLA-typed, and none had excess antigens. Family studies also indicated that the patient had at least one HLA-A antigen that was probably not inherited. These findings suggest the possibility that transient hemopoietic engraftment can occur in transfused sickle cell patients with AIDS.

• Authors: O Castro, L Alarif, C Saxinger, W Frederick
• Journal: American journal of hematology (Am J Hematol) Vol. 26 Issue 3 Pg. 273-7 (Nov 1987) ISSN: 0361-8609 [Print] United States
• PMID: 3674006 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens

Topics

• Acquired Immunodeficiency Syndrome (complications, immunology, therapy)
• Adult
• Anemia, Sickle Cell (complications, immunology, therapy)
• Blood Transfusion
• Female
• HLA Antigens (analysis)
• Humans
• Male