The effect of tricyclic antidepressants on stress-induced heart rate changes in panic disorder patients.

Abstract

Eight panic disorder patients participated in a double-blind placebo-controlled infusion study designed to induce panic-anxiety in the laboratory both before and after treatment with tricyclic antidepressants. Pre-infusion heart rates for the first infusion were significantly higher than baseline both before and after treatment. The delta increase in pre-infusion heart rates from baseline and the ratios of pre-infusion heart rates to baseline values were not significantly different between before and after treatment conditions indicating similar levels of arousal during the two pre-infusion periods, while the pre-infusion anxiety ratings after treatment were significantly lower.

• Authors: V K Yeragani, J M Rainey, R Balon, R Berchou, H Lycaki, R Pohl
• Journal: Acta psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 76 Issue 3 Pg. 324-7 (Sep 1987) ISSN: 0001-690X [Print] United States
• PMID: 3673660 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Antidepressive Agents, Tricyclic
• Lactates
• Lactic Acid
• Isoproterenol

Topics

• Adult
• Antidepressive Agents, Tricyclic (pharmacology)
• Anxiety Disorders (drug therapy)
• Double-Blind Method
• Fear (drug effects)
• Female
• Heart Rate (drug effects)
• Humans
• Isoproterenol (pharmacology)
• Lactates (pharmacology)
• Lactic Acid
• Male
• Panic (drug effects)