Induction of synchronized relapses in SJL/J mice with chronic relapsing experimental allergic encephalomyelitis.

Abstract

Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) was induced in SJL/J mice by two injections of encephalitogenic emulsion. The majority of mice developed multiple relapses from day 22 to day 367 post injection. To induce synchronized relapses a third injection of the encephalitogenic emulsion was given. Almost all mice that received the third injection developed an acute, synchronized relapse with severe clinical signs within 7 to 11 days. Histologically, there was no difference between the lesions in the spontaneous versus the precipitated relapse. CR-EAE in SJL/J mice modified with the third injection offers an advantage of a reproducible and well-timed acute relapse, which allows precise dissection of the immunological events governing spontaneous relapses in chronic EAE.

• Authors: P B Kozlowski, G B Schuller-Lewis, H M Wisniewski
• Journal: Acta neuropathologica (Acta Neuropathol) Vol. 74 Issue 2 Pg. 163-8 ( 1987) ISSN: 0001-6322 [Print] Germany
• PMID: 3673507 (Publication Type: Journal Article)

Chemical References

• Antigens

Topics

• Animals
• Antigens (immunology)
• Central Nervous System (pathology)
• Encephalomyelitis, Autoimmune, Experimental (immunology, pathology, physiopathology)
• Female
• Mice
• Recurrence
• Time Factors