Neonatal ocular prophylaxis in the United States: is it still necessary?

Abstract

INTRODUCTION:

Much has changed since Credé reported that silver nitrate decreases the incidence of ophthalmia neonatorum. Prenatal screening and treatment of pregnant women for Neisseria gonorrhoeae became standard in the 1950s and for Chlamydia trachomatis in 1993. Neonatal gonococcal and chlamydial conjunctivitis are consequently uncommon today. Currently, only 0.5% erythromycin ophthalmic ointment is available in the United States (U.S.) for neonatal ocular prophylaxis, which is ineffective against C. trachomatis.

AREAS COVERED:

This article addresses the altered epidemiology of ophthalmia neonatorum in the U.S. since prophylactic practices began, the lack of data supporting ophthalmic erythromycin for prevention of neonatal gonococcal and chlamydial conjunctivitis, and the impact of prenatal screening and treatment of pregnant women for N. gonorrhoeae and C. trachomatis on conjunctivitis incidence. The authors discuss why erythromycin ophthalmic ointment is likely ineffective against gonococcal ophthalmia, including the development of macrolide resistance. Physiologic limitations and pharmacokinetic properties are considered with respect to ophthalmic erythromycin for the prevention of gonococcal and chlamydial conjunctivitis.

EXPERT OPINION:

Administration of erythromycin ophthalmic ointment for the prevention of neonatal conjunctivitis is not literature-supported. Prenatal screening and treatment of pregnant women is the most effective way to prevent ophthalmia neonatorum. National mandates for prophylaxis should be withdrawn.

• Authors: Susannah Franco, Margaret R Hammerschlag
• Journal: Expert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 21 Issue 5 Pg. 503-511 (05 2023) ISSN: 1744-8336 [Electronic] England
• PMID: 36691840 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Ointments
• Macrolides
• Erythromycin

Topics

• Infant, Newborn
• Female
• Humans
• Pregnancy
• United States (epidemiology)
• Ophthalmia Neonatorum (diagnosis, drug therapy, epidemiology)
• Anti-Bacterial Agents (therapeutic use)
• Ointments (therapeutic use)
• Drug Resistance, Bacterial
• Macrolides (therapeutic use)
• Gonorrhea (drug therapy, epidemiology, prevention & control)
• Erythromycin (therapeutic use)
• Chlamydia trachomatis