Abstract |
We report the localization of the gene for dihydropteridine reductase (DHPR) to the human chromosome region 4p15.3 by in situ hybridization using a cDNA probe to the enzyme. The distal end of the short arm of chromosome 4 is of considerable interest because the gene responsible for Huntington's disease is located in this region. Although this part of the chromosome is being extensively studied, DHPR is the first well-characterised gene to be assigned to the region. Restriction enzyme fragment length polymorphisms have been detected with a number of restriction endonucleases, including AvaII and MspI. These features may make the DHPR cDNA clone a useful probe not only for prenatal diagnosis of DHPR deficiency but also for linkage studies of Huntington's disease.
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Authors | R M Brown, H H Dahl |
Journal | Genomics
(Genomics)
Vol. 1
Issue 1
Pg. 67-70
(Sep 1987)
ISSN: 0888-7543 [Print] United States |
PMID | 3666748
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA
- Dihydropteridine Reductase
- NADH, NADPH Oxidoreductases
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Topics |
- Base Sequence
- Chromosome Banding
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- DNA
(genetics)
- Dihydropteridine Reductase
(genetics)
- Humans
- Karyotyping
- Molecular Sequence Data
- NADH, NADPH Oxidoreductases
(genetics)
- Nucleic Acid Hybridization
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