A comparison of nalbuphine and meperidine in treatment of postoperative pain.

The analgesic efficacy and side effect profile of nalbuphine 20 mg IV and of nalbuphine 40 mg IV were compared to those of meperidine 75 mg IM in the immediate postoperative period. Pain intensity, pain relief, additional analgesic requirements and the overall acceptability of the treatment were recorded for 150 patients. No significant differences were found between the groups for any of the efficacy variables. Peak analgesic effects occurred at 15 minutes in both nalbuphine groups and at 30 minutes in the meperidine group. The mean time to additional analgesic medication was approximately 207 minutes in each group. The incidence of nausea and vomiting with meperidine was 22 per cent (95 per cent confidence interval 10 to 34 per cent) and with nalbuphine 20 mg the incidence was two per cent (95%CI -2 to 6 per cent). This difference was significant (p less than 0.01). The difference between nalbuphine 40 mg (10 per cent, 95%CI 1 to 19 per cent) and meperidine, was not considered statistically significant (p = 0.17). The analgesic efficacy of nalbuphine 20 mg was indistinguishable from that of nalbuphine 40 mg and from that of meperidine 75 mg. The significantly lower incidence of nausea and vomiting with nalbuphine is a major advantage for a recovery room analgesic.
AuthorsE Hew, K Foster, R Gordon, E Hew-Sang
JournalCanadian journal of anaesthesia = Journal canadien d'anestheĢsie (Can J Anaesth) Vol. 34 Issue 5 Pg. 462-5 (Sep 1987) ISSN: 0832-610X [Print] CANADA
PMID3664914 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Morphinans
  • Meperidine
  • Nalbuphine
  • Abdomen (surgery)
  • Adult
  • Bone and Bones (surgery)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Meperidine (administration & dosage, adverse effects)
  • Middle Aged
  • Morphinans (administration & dosage)
  • Nalbuphine (administration & dosage, adverse effects)
  • Pain, Postoperative (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: