Pancreatic
neuroendocrine tumors (
PNETs) or
islet cell tumors are neuroendocrine
neoplasms that arise from cells of the endocrine and nervous system within the pancreas. Patients with
PNET sometimes do not show any symptoms, known as nonfunctioning (NF) sporadic
PNET. It is still debatable regarding the best approach in the NF for small
PNET. Currently, the surgical approach is considered the best; however, it is a highly invasive procedure, and it has a potentially high risk of complications as it requires a skilled and experienced operator. Herewith, we reported a 48-year-old female with incidentaloma of nonfunctioning
PNET (NF-
PNET) whose
tumor has been successfully treated with endoscopic ultrasound guided
radiofrequency ablation (EUSRA). There was no adverse event observed during and after the EUS procedure, and even 1 week after the procedure. One year later, abdominal magnetic resonance imaging (MRI) examination was carried out and size of the
tumor was significantly getting smaller where it could hardly be seen anymore. After 2 years of follow-up, the latest abdominal MRI study showed no solid part of the
tumor could be seen anymore. In conclusion, EUSRA can be an alternative option for incidentaloma of NF-
PNET management.