The value of HbA1 and fructosamine in predicting impaired glucose tolerance--an alternative to OGTT to detect diabetes mellitus or gestational diabetes.

Abstract

Glycosylated haemoglobin and glycosylated serum protein concentrations (fructosamine) have been monitored in patients suspected of diabetes mellitus (n = 183), in pregnant women suspected of gestational diabetes (n = 250) and in control groups (n = 184). The response to the standard 75 g oral glucose tolerance test was used to confirm or reject the diagnosis, using different criteria for detection of diabetes mellitus compared to detection of gestational diabetes. A slightly higher sensitivity was observed for fructosamine compared to glycosylated haemoglobin to detect impaired glucose tolerance (52 vs 44%) or gestational diabetes (17% vs 8%). For detection of diabetic oral glucose tolerance no difference was observed between glycosylated haemoglobin and fructosamine; sensitivity for both parameters was 67%. The results suggest that fructosamine is slightly more sensitive in detecting borderline-abnormal glucose tolerance, whereas no differences are observed for detection of clearly abnormal oral glucose tolerance tests.

• Authors: T H Salemans, M P van Dieijen-Visser, P J Brombacher
• Journal: Annals of clinical biochemistry (Ann Clin Biochem) Vol. 24 ( Pt 5) Pg. 447-52 (Sep 1987) ISSN: 0004-5632 [Print] England
• PMID: 3662394 (Publication Type: Journal Article)

Chemical References

• Glycated Hemoglobin A
• Hexosamines
• Fructosamine

Topics

• Administration, Oral
• Diabetes Mellitus (diagnosis)
• Female
• Fructosamine
• Glucose Tolerance Test (methods)
• Glycated Hemoglobin (analysis)
• Hexosamines (blood)
• Humans
• Pregnancy
• Pregnancy in Diabetics (diagnosis)
• ROC Curve