Abstract |
Systemic mastocytosis is a rare disorder characterised by the infiltration of many tissues by abnormal numbers of mast cells. Life-threatening episodes of bronchospasm and hypotension are common in response to a variety of triggers which cause mast cell degranulation. We present the case history of a patient with severe mast cell disease who successfully underwent splenectomy and portocaval anastomosis. Peri-operative therapy was directed towards mast cell stabilisation, and histamine-releasing drugs were avoided. Cardiovascular data, together with blood histamine levels and thrombin times, indicated that mast cell degranulation did not occur. A review of the current literature concerning mast cell disease as it relates to anaesthesia is presented and suggestions for the safe management of such cases are given.
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Authors | G B Smith, R J Gusberg, R H Jordan, B Kim |
Journal | Anaesthesia
(Anaesthesia)
Vol. 42
Issue 8
Pg. 861-7
(Aug 1987)
ISSN: 0003-2409 [Print] England |
PMID | 3661931
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Hemodynamics
- Histamine
(blood)
- Humans
- Male
- Mastocytosis
(blood, complications, physiopathology)
- Splenectomy
- Splenorenal Shunt, Surgical
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