[Lattice structure antacids and antacid mixtures].

Abstract

In the last years the importance of the evaluation of antacid compounds according to their neutralizing capacity decreased. Clinical investigations have shown that antacid mixtures of aluminum-magnesium hydroxide healed gastric an duodenal ulcers (neutralizing capacity 100-150 mmol/day) as well as H2 receptor antagonists and better than a placebo. By this the necessary daily dosage could be reduced essentially. This paper presents studies showing that lattice like structured antacids (e.g. Magaldrate) healed gastric and duodenal ulcers (neutralizing capacity 100-350 mmol/day) as well as Ranitidine (150 mg b.d.). Maintenance therapy should be evaluated critically because sufficient data are not available and mineral metabolism is changed significantly by extremely small dosages of aluminium-magnesium hydroxide antacids even in patients with normal kidney function.

• Authors: S E Miederer, C Schmidt
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 25 Suppl 3 Pg. 130-5 (Aug 1987) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Gitterförmige Antazida und Antazidagemische.
• PMID: 3660893 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antacids
• Aluminum Hydroxide
• magaldrate
• Ranitidine
• Magnesium Hydroxide

Topics

• Aluminum Hydroxide (therapeutic use)
• Antacids (therapeutic use)
• Drug Administration Schedule
• Duodenal Ulcer (drug therapy)
• Gastric Acidity Determination
• Humans
• Magnesium Hydroxide (therapeutic use)
• Peptic Ulcer (drug therapy)
• Ranitidine (therapeutic use)
• Recurrence
• Structure-Activity Relationship
• Wound Healing (drug effects)