The genetic animal model of reflex epilepsy in the Mongolian gerbil: differential efficacy of new anticonvulsive drugs and prototype antiepileptics.

Abstract

Four new anticonvulsive drugs were compared to four prototype antiepileptics regarding their differential efficacy, i.e. against tonic-clonic, myoclonic, and minor seizures, in reflex epilepsy in genetically epileptic gerbils. We distinguished at least three types of drugs: Phenytoin and ralitoline selectively prevented tonic-clonic seizures; the other drugs tested were active against all seizure types. However, carbamazepine and AHR-11748 were predominantly active against tonic-clonic seizures, whereas phenobarbital, valproate, gabapentin, and zonisamide equipotently suppressed both tonic-clonic and myoclonic seizures.

• Authors: G D Bartoszyk, M Hamer
• Journal: Pharmacological research communications (Pharmacol Res Commun) Vol. 19 Issue 6 Pg. 429-40 (Jun 1987) ISSN: 0031-6989 [Print] United States
• PMID: 3659116 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants

Topics

• Animals
• Anticonvulsants (pharmacology)
• Disease Models, Animal
• Electroshock
• Female
• Gerbillinae (genetics)
• Male
• Models, Genetic
• Seizures (genetics, prevention & control)