HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pulmonary function at 1 year of age in survivors of neonatal respiratory distress: a multivariate analysis of factors associated with sequelae.

Abstract
We studied pulmonary function 1 year after neonatal respiratory distress (RD) in 54 infants who had been treated at birth in the same neonatal intensive care unit. RD was related to hyaline membrane disease in 36 cases (group I) and to other causes in 18 cases (group II). Compared with predicted values, dynamic lung compliance (CL) was lower (less than -2 SD) and total pulmonary resistance (RL) was higher (+2 SD) in 18 (33%) and 12 (22%) infants, respectively. The relationships between these functional abnormalities at 1 year of age and the characteristics of the neonatal respiratory disease were assessed using a multifactorial analysis (multiple correspondences analysis). We found that elevated RL (greater than +2 SD) at 1 year of age was very significantly related with hyaline membrane disease, involving both high rate of positive pressure ventilation and prolonged intubation, and with the presence of both tachypnea and abnormal chest X rays at the time of discharge. Compared with elevated RL, the relationships between low CL (less than -2 SD) and the same neonatal characteristics were less significant; in particular, there was no strong link between low CL and hyaline membrane disease. Finally, birth before 30 weeks gestation was an index of severity.
AuthorsG Moriette, C Gaudebout, A Clement, M Boule, B Bion, J P Relier, C Gaultier
JournalPediatric pulmonology (Pediatr Pulmonol) 1987 Jul-Aug Vol. 3 Issue 4 Pg. 242-50 ISSN: 8755-6863 [Print] United States
PMID3658529 (Publication Type: Journal Article)
Topics
  • Bronchopulmonary Dysplasia (physiopathology)
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaline Membrane Disease (physiopathology)
  • Infant
  • Infant, Newborn
  • Lung (physiopathology)
  • Lung Compliance
  • Male
  • Respiratory Distress Syndrome, Newborn (physiopathology)
  • Risk Factors
  • Statistics as Topic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: