[Role of disorders of calcium homeostasis in the development of ischemic contracture of the heart].

Abstract

The development of ischemic contracture in rat was evaluated in relation to glycolytic production of ATP and Ca2+ homeostasis. When the rate of glycolysis was reduced by glycogen depletion (swimming at 33 degrees C for 2 h, administration of isoprenaline or heart perfusion with it), the rate of ischemic contracture development increased. Isoprenaline increased the development of contracture in a dose-dependent manner, and dexamethasone potentiated the effect of isoprenaline. The decrease in the intensity of ATP/P1 exchange, probably reflecting the intensity of glycolytic phosphorylation of ADP, which, in our conditions, arose from ATP hydrolyzed mostly by Ca2+-ATPase and Na, K-ATPase, correlated with the development of ischemic contracture. Experiments with the rapid equilibration of the extracellular compartment with Ca2+ in various concentrations in the presence or absence of verapamil suggest that the development of ischemic contracture depends on the rate of Ca2+ accumulation in myoplasm. This rate of Ca2+ accumulation correlates with the rate of glycogenolysis and glycolysis which seems to produce ATP for active transport of cations.

• Authors: P K Kyrge, E L Vigel, G N Miannik
• Journal: Kardiologiia (Kardiologiia) Vol. 27 Issue 7 Pg. 76-80 (Jul 1987) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Znachenie narusheniĭ gomeostaza kal'tsiia v mekhanizme razvitiia ishemicheskoĭ kontraktury serdtsa.
• PMID: 3656924 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adenosine Triphosphate
• Glycogen
• Calcium

Topics

• Adenosine Triphosphate (deficiency)
• Animals
• Calcium (metabolism)
• Coronary Disease (etiology, metabolism)
• Glycogen (deficiency)
• Glycolysis
• Homeostasis
• Myocardium (metabolism)
• Rats
• Rats, Inbred Strains