Abstract |
Levels of immunoreactive (IR) oxytocin (OT)-associated or estrogen-stimulated neurophysin (ESN) and vasopressin-associated or nicotine-stimulated neurophysin (NSN) were measured in plasma of patients with chronic renal failure before and after hemodialysis (HD) and intermittent peritoneal dialysis (IPD), and during continuous ambulatory peritoneal dialysis ( CAPD). ESN-IR in 17 patients before HD was 24.4 +/- 2.7 ng/ml (mean +/- SEM) and increased after HD to 33.2 +/- 4.1 ng/ml (P less than 0.001). ESN-IR in 17 patients with CAPD was 15.2 +/- 3.4 ng/ml, significantly lower than in patients undergoing HD, P less than 0.001. In patients receiving IPD (n = 6), ESN was 11.6 +/- 3.7 ng/ml and did not change significantly after IPD. Levels of ESN in patients with renal failure were increased compared with levels in normal individuals, 1.0 +/- 0.1 ng/ml. Levels of ESN were not correlated with laboratory parameters that may be abnormal in renal failure. NSN levels in 16 of 17 patients undergoing HD were 3.2 +/- 0.34 ng/ml and in 14 of 17 patients with CAPD were 2.9 +/- 0.4 ng/ml, respectively. ESN before HD (r = 0.63, P less than 0.01), after HD (r = 0.85, P less than 0.001), and in patients with CAPD (r = 0.83, P less than 0.001) and IPD (r = 0.81, P less than 0.05) correlated significantly with an OT-like peptide previously found to be increased in renal failure.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | J A Amico, M R Silver, F M Finn, A G Robinson |
Journal | The Journal of laboratory and clinical medicine
(J Lab Clin Med)
Vol. 110
Issue 4
Pg. 439-47
(Oct 1987)
ISSN: 0022-2143 [Print] United States |
PMID | 3655523
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Estrogens
- Neurophysins
- Vasopressins
- Oxytocin
- Nicotine
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Topics |
- Adult
- Aged
- Chromatography, High Pressure Liquid
- Estrogens
(pharmacology)
- Humans
- Kidney Failure, Chronic
(blood)
- Middle Aged
- Neurophysins
(blood)
- Nicotine
(pharmacology)
- Oxytocin
(analysis)
- Peritoneal Dialysis
- Peritoneal Dialysis, Continuous Ambulatory
- Pituitary Gland, Posterior
(analysis)
- Renal Dialysis
- Vasopressins
(analysis)
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