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Assessment of the permeability of the blood-retinal barrier in hypertensive rats.

Abstract
We assessed the permeability surface area products at the blood-retinal barrier and blood-brain barrier to sucrose (molecular weight, 340) and microperoxidase (molecular weight, 2000) following acute hypertension induced by metaraminol in Wistar-Kyoto rats (controls) and during chronic hypertension in spontaneously hypertensive rats. In acute hypertension, the permeability surface area product for sucrose was increased at the blood-retinal barrier and at the blood-brain barrier over control values (p less than 0.02), and the vessels became leaky to microperoxidase. In chronic hypertension, the permeability of the blood-retinal barrier to sucrose was increased over that in control animals (p less than 0.02), whereas the permeability of the blood-brain barrier was unaffected. Neither barrier leaked microperoxidase. These results indicate that the blood-brain barrier and the blood-retinal barrier are similarly affected in acute hypertension and that in chronic hypertension, the blood-brain barrier is unaffected whereas the blood-retinal barrier is rendered more permeable to small, but not large, solutes.
AuthorsS Lightman, E Rechthand, C Latker, A Palestine, S Rapoport
JournalHypertension (Dallas, Tex. : 1979) (Hypertension) Vol. 10 Issue 4 Pg. 390-5 (Oct 1987) ISSN: 0194-911X [Print] United States
PMID3653967 (Publication Type: Journal Article)
Chemical References
  • Sucrose
  • Metaraminol
  • Peroxidases
  • microperoxidase
Topics
  • Acute Disease
  • Animals
  • Blood-Brain Barrier
  • Blood-Retinal Barrier
  • Chronic Disease
  • Hypertension (chemically induced, genetics, physiopathology)
  • Metaraminol
  • Permeability
  • Peroxidases (pharmacokinetics)
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Sucrose (pharmacokinetics)

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