7-Ethoxyresorufin deethylase (EROD) in human liver--the effect of alcoholic liver disease.

Abstract

We have investigated the effect of alcoholic liver disease (ALD) on the metabolism of 7-ethoxycoumarin 0-deethylase in human liver microsomes. EROD activity was significantly reduced in tissue from ALD patients who smoked, compared to smoking controls. A similar trend was seen in non-smokers. These results have implications for the metabolism of environmental carcinogens.

• Authors: K W Woodhouse, E Mutch, F M Williams, O F James, M D Rawlins
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 32 Issue 6 Pg. 559-62 ( 1987) ISSN: 0031-6970 [Print] Germany
• PMID: 3653224 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Environmental Pollutants
• Oxidoreductases
• Cytochrome P-450 CYP1A1

Topics

• Adult
• Cytochrome P-450 CYP1A1
• Environmental Pollutants (metabolism)
• Female
• Humans
• Liver (enzymology)
• Liver Diseases, Alcoholic (enzymology)
• Male
• Middle Aged
• Oxidoreductases (analysis)