Abstract |
Fluid phase C3 conversion by C3 nephritic factor (C3NeF) is usually easily detectable and forms the basis of the C3NeF screening test. We have described a group of patients with membranoproliferative glomerulonephritis or partial lipodystrophy and hypocomplementaemia who have an unusual C3NeF which stabilizes cell-bound C3 convertase of the alternative pathway (C3bBb) but causes such weak fluid phase C3 conversion that a C3NeF screening test is negative. These patients have low concentrations of C5 in serum.
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Authors | Y C Ng, D K Peters |
Journal | Clinical and experimental immunology
(Clin Exp Immunol)
Vol. 65
Issue 2
Pg. 450-7
(Aug 1986)
ISSN: 0009-9104 [Print] England |
PMID | 3641695
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Complement C3 Nephritic Factor
- Complement C5
- Complement Inactivator Proteins
- Immunoglobulin G
- Complement Activating Enzymes
- Complement C3-C5 Convertases
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Topics |
- Adolescent
- Adult
- Child
- Complement Activating Enzymes
(blood)
- Complement Activation
- Complement C3 Nephritic Factor
(analysis)
- Complement C3-C5 Convertases
(blood)
- Complement C5
(analysis)
- Complement Inactivator Proteins
(analysis)
- Complement Pathway, Alternative
- Female
- Glomerulonephritis
(immunology)
- Humans
- Immunoglobulin G
(immunology)
- Lipodystrophy
(immunology)
- Male
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